You can save a few pounds, we saved 5-10 lbs on the 4 rear windows plus hardware for the two pop outs on our XR4Ti, we saved another 15 lbs by removing the sunroof/tray/mechanicals and riveting in a piece of Lexan. Luckily GA has no rules on vehicles including safety inspections even in the covered counties that have pollution controls (Atlanta Metro area). Other than passing smog you could be missing doors, windows, etc, though I'm sure a cop would pull you over and cite you for endangering the public :)
We used 3/8" and it's insanely strong, like we've beat it with hammers just for giggles after we riveted it in and it just bounces the hammer, same thing would have smashed the old windows. That being said they're prolly not used in cars cause it does scratch, it needs a UV protector layer which must face outwards or else it yellows, and while flexible it's hard to mold it to shape so if you wanted to install it on curved window surfaces you'd need a better way to adhere it than simple epoxy like normal shaped windows, like I said we had to rivet them in place...