I built a call center a few years ago. For under $200,000 worth of renovations to an existing grocery store, a major company was able to move in and created over 150 jobs averaging $15 per hour in a place where minimum wage jobs are truly scare. The ONLY connection a business like this needs to the outside world is a phone line. They shipped no product, manufactured nothing.
Any business that sells online or over the phone could use a similar center, and could locate it anywhere.
The only thing a business like that needs to be interested is a cooperative local environment and a willing and trainable work force. I'll bet local government would offer business incentives, etc., and costs could be low enough to entice a company in.
A creative person partnering with a company like that and offering people "rent to own" scenarios along with decent jobs could get thousands of people willing to relocate, especially if they are dealing with a large enough quantity of properties that they can have an impact on improving a neighborhood.
Boxes were meant to be busted out of.