The comments about the quality of the shoes' construction are also interesting. These things (Ariat) are quite solid, but definitely a couple orders of magnitude of lesser quality than the last few pairs I've had (Magnum, Bates, Garamont, Hi Tec), and decidedly sweatshop-made, which I usually try to avoid, especially with shoes/boots.
I think I have a Perfect Storm of foot funk going on: a minimally-breathable waterproof lining, cheap leather, cheap socks, and generally low quality materials that might be reacting with my personal chemistry, all combined with a near-constant wear pattern, giving them no time to recover.
I wouldn't be surprised if they're harboring a fair amount of bacteria. I'll definitely give them a super-deluxe-kill-the-bastards treatment this weekend, when I have some time to give them a break.
Some after-Xmas sales will see me stocking up on socks, for sure. I'll be happy to trash the pairs I'm wearing now.
And I've already got my eye on a couple different pairs of Red Wings, if Santa leaves a couple bucks in my budget for personal use.