I own a '66 F-100, and used to own a '65 F-250 which was basically the same thing as a 1966. The 352/4 speed combo is reliable and strong. The rear axle ratio may be too steep for comfortable highway driving (my F-250 had 4.56 gears, it sounded like it was going to explode at 60mph) but since this one is a Camper Special it may have more highway friendly gears. edit: I just looked it up and a Camper Special F-250 had 4.10 gears stock.
The Camper Special option mainly consisted of a heavy duty suspension, radiator and battery, and west coast mirrors. You could get them with a longer wheelbase and a 9 foot long bed, but the vast majority came with a regular 8 foot bed.
Most likely it has manual steering and brakes; the brakes aren't so bad to live with but manual steering can be a bear if you don't have some good upper body strength. The tip is to get the truck rolling a little before you turn the wheel. You'll definitely know you're driving a truck...they're pretty primitive compared to today's vehicles.
Rust can be a problem. The most important place to look is in the front cab supports (you can see them inside the front wheelwells.) They can rust out completely and let the front of the cab sag. You can see the sag by sighting down the side of the truck, plus it can bind up the steering wheel. Almost all F series trucks of that era will have rust in the radiator support, it's hidden down behind the grille were you can't see it but more often than not it's going to be there.
The bed floor can rust out where it meets the front of the bed, also the bottom of the tailgate. In general they can rust most anywhere (rockers, floors, etc.) but these are the most likely locations.
In general they're not much more complicated than a lawn mower to work on, and parts availability is good. There are several companies selling reproduction parts, Dennis Carpenter and Auto Krafters are two I can think of offhand.
There are some easy upgrades from newer trucks, in particular the disk brakes and power steering from newer trucks up to 1979 are more or less a bolt in. The Slick 60s link above is good, there's also http://www.ford-trucks.com/