With a long commute, I value the option of quiet and comfort. I drive my relatively loud Mustang during from Spring until the snow first flies, but I have the option of taking something quieter when I can't deal with the noise. If I had to pick only one car to do a commute in, something quiet and comfortable would get my vote.
I'd say: BMW 540 or 740. The V8 is a nice motor and it doesn't do bad on the highway for mileage and the chassis is nice and comfy while being responsive.
m4ff3w on this forum has a 540 6 spd and he's averaged ~22 over the time he's owned it with a lot of highway driving, iirc.
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