The answer to your questions will vary heavily by engine, because there is so much variation in power cylinder geometry, compression ratios, specific output, cam design, VE, etc.
Yes, steady state is typically more efficient than transient operation. Most engines I've worked with have some combination of preemptive ignition retard and acceleration enrichment that hurt you during rapid transients.
Drive by wire can be used for this, but I've only seen it done in some motorcycle application where the "base" model had limited throttle and the higher end model allowed the throttle to open fully. Not for economy though, just for horsepower differentiation between models.
I've only seen cars limit throttle openings to control cylinder pressure in specific situations (low RPM lugging, basically only limited near idle speed), never explicitly for BSFC. I don't think it would help for BSFC because you're incurring throttling losses, which are inherently inefficient.
Most of the questions in your original post (limit RPM, limit airflow through restrictors/throttle control/etc) will not help BSFC necessarily, but would reduce fuel consumption. Reducing BSFC means doing the same work with less, as opposed to using less but also doing less. However, they may put you in a part of the engine operating map that happens to have higher BSFC, again depending on how the engine is designed. For example, engine might make the most power around redline, but if peak BSFC is at a lower engine speed, a lower rev limit might keep the driver in that high BSFC range.
I would guess (because I've never tried it) that most modern engines are tuned well for BSFC within a particular rev range until you get to the last 10-15% of throttle opening or whenever they come out of closed loop. At the expensve of power, in that open loop region you could probably back off timing and work your way up towards stoich to see how close you can get without knock at WOT, or without melting things. If temperatures go crazy, then use electronic throttle to limit airflow/cylinder pressure to where the engine can handle it.
Of course, generally speaking anything you can do to reduce intake and exhaust restrictions will also have some positive impact on BSFC.