I'm no cam expert but I built enough high performance engines and spent lots of time picking cams (or lobes) for many of the engines. Even ordered the first 4 pattern cam for a small block Mopar to put in a customer engine.
Single vs Dual pattern: IMO a single pattern seems like it was just easy and no real effort went in R&D. I come to this conclusion because most cams that did get extensive R&D are dual pattern. The dual pattern is less about flow and more about the timing of peak flow/velocity and its ability to generate favorable overlap conditions.
Someone much smarter than me at developing racing heads and cams once said "don't worry about the exh, It flows enough, focus your time on getting the air in". Think about how hard it is to get air into a cylinder when it's relying on a few inches of vacuum to do it...now how easy is it to get the exhaust out when it has a hundreds if not over a thousand PSI forcing it out. There are studies out there that point to 90% or more of the exhaust flow is completed in the first few degrees of exhaust valve opening. Long before it ever reaches peak lift. So the logical question is why are there even big exhaust lobes in use? Why not just have small lift and duration exh? Well it has to do with getting air in the cylinder on the intake stroke. Think about it...it there's still 10% exhaust gas in the cylinder...you now have that much less room for fresh air/fuel. If the exhaust valve is already closed, then there is no overlap effect. Then there is the residual pressure that would be there if the exhaust was closed before reaching TDC and starting the intake stroke. That pressure would try to go up the intake as soon as the intake valve opened up. (this effect is also why you don't want a restrictive exhaust system)
This is not to say that the exhaust flow doesn't matter, just that its only requirement it to be enough in regards to flow. What's way more important is the velocity and pressures involved. Every flowed a head backwards? A port that resists reversion by say 30cfm is going to make more power than one that flows 5cfm more but only resists reversion by 10cfm. During R&D if I made a back-cut angle change to a valve that picked up 3-5 cfm on the intake and ALSO lost a few cfm of reverse flow, that is a good improvement! If it gained more reverse flow then I'm testing a different angle or cut width or whatever I need to. Air moves through an engine like AC current (back and forth) but we really only want it to go one way. The entire engine combination affects this. Especially the cam, head, intake, exhaust.
What's optimal? Depends on everything in you combo. Change the intake manifold? Its likely the perfect cam is now different too. But since we're not building Formula 1 engines getting in the ball park is good enough for improvements. Get your entire engine combo in the ball park so that it all works together and now you have a combo that works. Perfect example is crate engine. Lets say it makes 450HP, I could pull it apart do a little extra machine work, change the valve job, add a back-cut, pick a different cam, maybe change the intake or port it, clean up the ports in the head, and many other small changes. Now it makes over 500hp, gained torque everywhere, idles better and runs smoother. With nearly all the same original parts.
Getting back to the main topic. Single vs dual pattern is barely looking in the rabit hole. Want to go deep you need to start looking at and figuring out how to calculate pressures, velocity, timing of those in relation to the cam, the head, the intake, the exhaust. Then now lets look at lift, duration, overlap, centerline....change one, it all changes. Might be a small change or a huge one. Not enough for you? Lets look at asymmetrical lobes (different opening and closing ramps) and 4 pattern cams. 4 Pattern cam? On a V8 to get the cylinders evenly running it has been found that the longer runners (1,2,7,8 on a GM) need 2-8 degrees more duration to get the same power production as the short runner cylinders. A whole n'other can of worms to look at when designing on of these.